Closure Therapy
In adults, patent ductus arteriosus (PDA) closure is recommended if left atrial or left ventricular enlargement is attributable to the PDA with left-to-right shunt, pulmonary artery systolic pressure less than 50% systemic, and pulmonary vascular resistance less than one-third systemic.1
PDA closure in adults may be considered when there is evidence of left-to-right shunt if pulmonary artery systolic pressure is 50% or greater systemic, and/or pulmonary vascular resistance is greater than one-third systemic.1
Transcatheter PDA closure—e.g., with an Amplatzer™ Duct Occluder—is the standard of care in most cases.2
Clinical Data Overview
AP2947053-WBO Rev. A
- Stout KK, et al. 2018 AHA/ACC Guideline for the Management of Adults with Congenital Heart Disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2018;000:e000-e000. doi: 10.1161/CIR.0000000000000603.
- Baruteau AE, et al. Transcatheter closure of patent ductus arteriosus: past, present and future. Arch Cardiovasc Dis. 2014;107:122-132.