COMORBIDITIES, Symptoms, and Treatments for Congenital Heart Defects

VENTRICULAR SEPTAL DEFECT (VSD)

A VSD is common in both children and adults second only to bicuspid aortic valves as the most common congenital heart defect. Spontaneous closure occurs most often in muscular defects; it also occurs in 35%-40% of patients with perimembranous defects. Spontaneous closure frequently occurs in children, usually by age 2 years; it is uncommon after age 4.1

Data show that spontaneous closure is decreased in patients who have VSD in addition to patent ductus arteriosus (PDA), likely because PDA further increases left-to-right shunt and leads to more severe hemodynamic effects.2

TYPES OF VENTRICULAR SEPTAL DEFECTS

There are 4 types of VSDs:

  1. Perimembranous VSDs—the most common, composing 80% of VSDs—are located in the membranous septum, adjacent to the septal leaflet of the tricuspid valve. On the left ventricular (LV) side, the defect is adjacent to the aortic valve.
  2. Muscular VSDs can be located centrally, at the apex, or at the margin of the septum and right ventricular free wall. Although muscular VSDs account for up to 20% of VSDs in infants, spontaneous closure reduces their incidence in adults.
  3. Conal or subpulmonary VSDs, found just beneath the pulmonary and aortic valves, occur in about 6% of defects in non-Asian populations and up to 33% in Asian populations. Spontaneous closure is uncommon.
  4. Inlet VSDs, which occur in the lower right ventricle and adjacent to the tricuspid valve, typically occur in patients with Down syndrome.

CARDIOVASCULAR EFFECTS OF VENTRICULAR SEPTAL DEFECTS

A left-to-right shunt resulting from the VSD can result in:

  • Increased LV volume load
  • Excessive pulmonary blood flow
  • Reduced systemic cardiac output
  • Elevated pulmonary artery pressures

COMPLICATIONS FROM VENTRICULAR SEPTAL DEFECTS1

Even though patients with small perimembranous VSDs tend to have good outcomes, that category of VSD is associated with an increased risk of:

  • Aortic valve prolapse
  • Malignant ventricular arrhythmias

Eisenmenger complex is the most severe complication of a large VSD. Irreversible pulmonary hypertension develops, resulting in the left-to-right shunt reversing to become a right-to-left shunt. Patients with Eisenmenger syndrome require therapy.

CONTRIBUTING FACTORS TO VENTRICULAR SEPTAL DEFECTS

Among the contributing factors are:

  • A congenital cardiovascular defect in a parent or sibling
  • Maternal diabetes
  • Maternal alcohol consumption (for muscular VSD)

VSDs are the most common lesion in many chromosomal syndromes, including trisomy 13, trisomy 18, trisomy 21, and other more rare syndromes. However, for more than 95% of patients with VSDs, there is no association with a chromosomal abnormality.1

Symptoms Correspond to VSD Size

Defect size as noted below is presented as a percentage of the aortic annulus diameter.

A small VSD of ≤ 25% has small left-to-right shunts and no LV volume overload. These VSDs usually have a very good prognosis but the defect can:

  • Present as a systolic murmur
  • Put the patient at risk for infective endocarditis
  • For perimembranous VSDs, present an increased risk for aortic cusp prolapse

A moderate VSD of > 25% but < 75% has moderate LV volume overload, and mild or no PAH. Patients may present with:

  • No symptoms
  • Symptoms of mild congestive heart failure

A large VSD of ≥ 75% has a moderate to large shunt, LV volume overload, and PAH. Infants with a large VSD have symptoms including:

  • Dyspnea
  • Tachypnea
  • Perspiration
  • Fatigue while feeding
  • Poor weight gain

Other Symptoms in Adults

An adult with a VSD may present with:

  • A systolic murmur previously thought to be an innocent murmur
  • Fever and bacteremia from infective endocarditis
  • A new diastolic murmur indicating aortic regurgitation due to aortic valve prolapse
  • Cyanosis and exercise intolerance due to the progressive development of pulmonary vascular disease

DIAGNOSTIC EVALUATION

Doppler echocardiography is the primary means of diagnosing VSDs.

Treatment for Ventricular septal defectS

Abbott offers effective treatment for VSD.
 

Amplatzer VSD Occluders


The information provided is not intended for medical diagnosis or treatment as a substitute for professional advice.  Consult with a physician or qualified healthcare provider for appropriate medical advices.

AP2947078-WBO Rev. A

References
  1. Ramaswamy P. Ventricular septal defects. Medscape. https://emedicine.medscape.com/article/892980-overview. Accessed August 28, 2018.
  2. Xu Y, et al. Factors influencing the spontaneous closure of ventricular septal defect in infants. Int J Clin Exp Pathol. 2015;8(5):5614-5623.
     

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